Dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a Coronavirus Disease 2019 patient
Identifieur interne : 000708 ( Main/Exploration ); précédent : 000707; suivant : 000709Dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a Coronavirus Disease 2019 patient
Auteurs : Ding-Feng Lv [République populaire de Chine] ; Qi-Ming Ying [République populaire de Chine] ; Yue-Song Weng [République populaire de Chine] ; Chi-Bin Shen [République populaire de Chine] ; Jin-Guo Chu [République populaire de Chine] ; Jing-Ping Kong [République populaire de Chine] ; Ding-He Sun [République populaire de Chine] ; Xiang Gao [République populaire de Chine] ; Xing-Bei Weng [République populaire de Chine] ; Xue-Qin Chen [République populaire de Chine]Source :
- Clinica Chimica Acta; International Journal of Clinical Chemistry [ 0009-8981 ] ; 2020.
Abstract
We report the dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a COVID-19 patient: from successive negative results to successive single positive nucleocapsid gene, to two positive target genes (
Url:
DOI: 10.1016/j.cca.2020.03.032
PubMed: 32229107
PubMed Central: 7118663
Affiliations:
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Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af030">Department of General Practice, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Practice, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Kong, Jing Ping" sort="Kong, Jing Ping" uniqKey="Kong J" first="Jing-Ping" last="Kong">Jing-Ping Kong</name><affiliation wicri:level="1"><nlm:aff id="af015">Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation 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Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Blood Transfusion, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af015">Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Ying, Qi Ming" sort="Ying, Qi Ming" uniqKey="Ying Q" first="Qi-Ming" last="Ying">Qi-Ming Ying</name><affiliation wicri:level="1"><nlm:aff id="af005">Department of Blood Transfusion, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Blood Transfusion, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af010">Department of Blood Transfusion, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Blood Transfusion, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Weng, Yue Song" sort="Weng, Yue Song" uniqKey="Weng Y" first="Yue-Song" last="Weng">Yue-Song Weng</name><affiliation wicri:level="1"><nlm:aff id="af015">Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Shen, Chi Bin" sort="Shen, Chi Bin" uniqKey="Shen C" first="Chi-Bin" last="Shen">Chi-Bin Shen</name><affiliation wicri:level="1"><nlm:aff id="af015">Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Jin Guo" sort="Chu, Jin Guo" uniqKey="Chu J" first="Jin-Guo" last="Chu">Jin-Guo Chu</name><affiliation wicri:level="1"><nlm:aff id="af025">Department of General Practice, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Practice, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af030">Department of General Practice, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of General Practice, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Kong, Jing Ping" sort="Kong, Jing Ping" uniqKey="Kong J" first="Jing-Ping" last="Kong">Jing-Ping Kong</name><affiliation wicri:level="1"><nlm:aff id="af015">Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Ding He" sort="Sun, Ding He" uniqKey="Sun D" first="Ding-He" last="Sun">Ding-He Sun</name><affiliation wicri:level="1"><nlm:aff id="af015">Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><affiliation wicri:level="1"><nlm:aff id="af035">Department of Neurosurgery, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af040">Department of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurosurgery, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Weng, Xing Bei" sort="Weng, Xing Bei" uniqKey="Weng X" first="Xing-Bei" last="Weng">Xing-Bei Weng</name><affiliation wicri:level="1"><nlm:aff id="af015">Department of Laboratory Medicine, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af020">Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Laboratory Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Xue Qin" sort="Chen, Xue Qin" uniqKey="Chen X" first="Xue-Qin" last="Chen">Xue-Qin Chen</name><affiliation wicri:level="1"><nlm:aff id="af045">Department of Chinese Traditional Medicine, Ningbo First Hospital, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Traditional Medicine, Ningbo First Hospital, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af050">Department of Chinese Traditional Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Traditional Medicine, Ningbo Hospital, Zhejiang University School of Medicine, Ningbo</wicri:regionArea><wicri:noRegion>Ningbo</wicri:noRegion></affiliation></author></analytic><series><title level="j">Clinica Chimica Acta; International Journal of Clinical Chemistry</title><idno type="ISSN">0009-8981</idno><idno type="eISSN">1873-3492</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We report the dynamic change process of target genes by RT-PCR testing of SARS-Cov-2 during the course of a COVID-19 patient: from successive negative results to successive single positive nucleocapsid gene, to two positive target genes (<italic>orf</italic>1ab and nucleocapsid) by RT-PCR testing of SARS-Cov-2, and describe the diagnosis, clinical course, and management of the case. In this case, negative results of RT-PCR testing was not excluded to diagnose a suspected COVID-19 patient, clinical signs and symptoms, other laboratory findings, and chest CT images should be taken into account for the absence of enough positive evidence. This case highlights the importance of successive sampling and testing SARS-Cov-2 by RT-PCR as well as the increased value of single positive target gene from pending to positive in two specimens to diagnose laboratory-confirmed COVID-19.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lu, R" uniqKey="Lu R">R. Lu</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X. Zhao</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Saminathan, M" uniqKey="Saminathan M">M. Saminathan</name></author><author><name sortKey="Chakraborty, S" uniqKey="Chakraborty S">S. Chakraborty</name></author><author><name sortKey="Tiwari, R" uniqKey="Tiwari R">R. Tiwari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhu, N" uniqKey="Zhu N">N. Zhu</name></author><author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wu, F" uniqKey="Wu F">F. Wu</name></author><author><name sortKey="Zhao, S" uniqKey="Zhao S">S. Zhao</name></author><author><name sortKey="Yu, B" uniqKey="Yu B">B. Yu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Wei Jie" uniqKey="Guan W">Wei-jie Guan</name></author><author><name sortKey="Zheng Yi Ni, Yuhu" uniqKey="Zheng Yi Ni Y">YuHu Zheng-yi Ni</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Lv, Ding Feng" sort="Lv, Ding Feng" uniqKey="Lv D" first="Ding-Feng" last="Lv">Ding-Feng Lv</name></noRegion><name sortKey="Chen, Xue Qin" sort="Chen, Xue Qin" uniqKey="Chen X" first="Xue-Qin" last="Chen">Xue-Qin Chen</name><name sortKey="Chen, Xue Qin" sort="Chen, Xue Qin" uniqKey="Chen X" first="Xue-Qin" last="Chen">Xue-Qin Chen</name><name sortKey="Chu, Jin Guo" sort="Chu, Jin Guo" uniqKey="Chu J" first="Jin-Guo" last="Chu">Jin-Guo Chu</name><name sortKey="Chu, Jin Guo" sort="Chu, Jin Guo" uniqKey="Chu J" first="Jin-Guo" last="Chu">Jin-Guo Chu</name><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><name sortKey="Gao, Xiang" sort="Gao, Xiang" uniqKey="Gao X" first="Xiang" last="Gao">Xiang Gao</name><name sortKey="Kong, Jing Ping" sort="Kong, Jing Ping" uniqKey="Kong J" first="Jing-Ping" last="Kong">Jing-Ping Kong</name><name sortKey="Kong, Jing Ping" sort="Kong, Jing Ping" uniqKey="Kong J" first="Jing-Ping" last="Kong">Jing-Ping Kong</name><name sortKey="Lv, Ding Feng" sort="Lv, Ding Feng" uniqKey="Lv D" first="Ding-Feng" last="Lv">Ding-Feng Lv</name><name sortKey="Lv, Ding Feng" sort="Lv, Ding Feng" uniqKey="Lv D" first="Ding-Feng" last="Lv">Ding-Feng Lv</name><name sortKey="Lv, Ding Feng" sort="Lv, Ding Feng" uniqKey="Lv D" first="Ding-Feng" last="Lv">Ding-Feng Lv</name><name sortKey="Shen, Chi Bin" sort="Shen, Chi Bin" uniqKey="Shen C" first="Chi-Bin" last="Shen">Chi-Bin Shen</name><name sortKey="Shen, Chi Bin" sort="Shen, Chi Bin" uniqKey="Shen C" first="Chi-Bin" last="Shen">Chi-Bin Shen</name><name sortKey="Sun, Ding He" sort="Sun, Ding He" uniqKey="Sun D" first="Ding-He" last="Sun">Ding-He Sun</name><name sortKey="Sun, Ding He" sort="Sun, Ding He" uniqKey="Sun D" first="Ding-He" last="Sun">Ding-He Sun</name><name sortKey="Weng, Xing Bei" sort="Weng, Xing Bei" uniqKey="Weng X" first="Xing-Bei" last="Weng">Xing-Bei Weng</name><name sortKey="Weng, Xing Bei" sort="Weng, Xing Bei" uniqKey="Weng X" first="Xing-Bei" last="Weng">Xing-Bei Weng</name><name sortKey="Weng, Yue Song" sort="Weng, Yue Song" uniqKey="Weng Y" first="Yue-Song" last="Weng">Yue-Song Weng</name><name sortKey="Weng, Yue Song" sort="Weng, Yue Song" uniqKey="Weng Y" first="Yue-Song" last="Weng">Yue-Song Weng</name><name sortKey="Ying, Qi Ming" sort="Ying, Qi Ming" uniqKey="Ying Q" first="Qi-Ming" last="Ying">Qi-Ming Ying</name><name sortKey="Ying, Qi Ming" sort="Ying, Qi Ming" uniqKey="Ying Q" first="Qi-Ming" last="Ying">Qi-Ming Ying</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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